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Genetic changes in Ebola may impede potential treatments: study
U.S. researchers studying the genetic makeup of Ebola currently circulating in West Africa said Tuesday they identified several mutations that could potentially interfere with the effectiveness of new drugs for the deadly virus.
"The (Ebola) virus mutates rapidly," Jeffrey Kugelman of the U. S. Army Medical Research Institute of Infectious Diseases ( USAMRIID), who is the study's first author, said in a statement. " And it's an ongoing concern."
In the U.S. journal mBio, Kugelman and colleagues described the "genomic drift," or natural evolution of the virus, and how it may interrupt the action of potential therapies designed to target the virus's genetic sequence.
According to the study, three types of genetic sequence-based treatments -- monoclonal antibody, small-interfering RNA and phosphorodiamidate morpholino oligomer drugs -- being evaluated during the current outbreak. All were developed using Ebola virus strains from two smaller outbreaks that occurred in 1976 and 1995.
Working with investigators from Harvard University and the Massachusetts Institute of Technology, the USAMRIID team compared the current strain, called EBOV/Mak, with the two previous strains that caused outbreaks in 1976 and 1995 in Zaire, now known as the Democratic Republic of the Congo.
In each comparison, the researchers found more than 600 genetic mutations, which account for about 3 percent of the genome.
The group also found that 10 new mutations that might interfere with the mechanisms of the sequence-based drugs currently being tested and that three of these mutations appeared during the current West African outbreak.
The researchers urged that drug developers should check whether these mutations affect the efficacy of their therapeutic drugs, which are being used to treat small numbers of patients under a World Health Organization (WHO) emergency protocol.
"The virus has not only changed since these therapies were designed, but it's continuing to change," Kugelman said. "Ebola researchers need to assess drug efficacy in a timely manner to make sure that valuable resources are not spent developing therapies that no longer work."
So far, there have been more than 21,000 Ebola cases with more than 8,300 deaths since the outbreak began last year in Liberia, Sierra Leone and Guinea, according to the World Health Organization.
[Source: Xinhua, Washington, 20Jan15]
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